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Melatonin instruction, price on the Internet

Melatonin instruction, price on the Internet

Composition and release form

Composition

Active ingredient: Melatonin – N-acetyl-5-methoxytryptamine and N- [2- (5-Methoxy-1H-indol-3-yl) ethyl] acetamide – 3 mg. Excipients: Anhydrous dibasic calcium phosphate, Microcrystalline cellulose, Croscarmelose sodium, colloidal silicon dioxide, Magnesium stearate, Stearic acid – 297 mg.

Release form

Capsules

pharmachologic effect

Melatonin instruction, price on the Internet

Melatonin is a substance produced by the pineal gland, the pineal gland, located at the base of the brain. Melatonin is found in plant foods, but to a much lesser extent than in animal foods. Scientific and clinical studies have shown that the synthesis and secretion of melatonin depend on light intensity – an excess of light inhibits its formation, and a decrease increases it. In humans, night hours account for 70% of the daily production of melatonin. Melatonin secretion is subject to the circadian rhythm, which, in turn, determines the rhythm of gonadotropic effects and sexual function, as well as the stabilization of cumulative changes in the intensity of metabolism and energy caused by changes in ambient light. This property includes changes in reproductive organs, body weight, mental behavior and manners. Experimental data suggests that under the influence of melatonin, the content of gamma-aminobutyric acid and serotin in the midbrain and hypothalamus increases. It is known that gamma-aminobutyric acid is an inhibitory mediator in the central nervous system, and a decrease in the activity of serotonergic mechanisms may be important in the pathogenesis of depressive states and disorders. The essential amino acid L-Tryptophan, which is a precursor in the synthesis of melatonin, is converted through two processes through serotin to melatonin, which is found mainly in the pineal gland. Melatonin is also known as N-acetyl-5-methoxytryptamine and N- [2- (5-Methoxy-1H-indol-3-yl) ethyl] acetamide.

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Melatonin is a solid, absorbing or dissolving fat, water-insoluble substance that is a powerful natural antioxidant. The body, synthesizing it, is protected from excessive formation of free radicals – metabolic products that cause rapid aging and cancer. Melatonin has a unique ability, unlike other antioxidants, to penetrate into any cell in any part of the body and exert a specific protective effect on the nucleus – the central structure of the cell containing DNA, i.e. on the structure that allows the damaged cell to recover. It is known that melatonin has a stimulating effect on the enzyme glutathion peroxidase, which has antioxidant properties. Melatonin can also exist in synthetic form, which is used as an additive that has hypnotic and antioxidant properties. This becomes relevant with the age of a person, when the activity of the endocrine glands of the body fades away. Melatonin production is entirely dependent on the biological clock of the human body and the change of the natural day-night cycle. Melatonin has antioxidant activity at sufficiently high pharmacological doses that can prevent the formation of free radicals. The action of the drug occurs within 60-120 minutes after ingestion.

Indications for use

    • insomnia;
    • states with disturbed sleep;
    • promotes sleep onset (delayed sleep phase syndrome);
    • helps to regulate the “sleep-awakening” biological cycle (especially with frequent and fast changes of several time zones);
    • as an antioxidant, protecting cells from the harmful effects of free radicals;
Melatonin instruction, price on the Internet
  • has a stimulating effect on the enzyme glutathione peroxidase, which has antioxidant properties;
  • stimulates the immune system;
  • stabilizes blood pressure and regulates the level of cholesterol in the blood;
  • positive effect on premenstrual state;
  • prevention of tumor diseases;
  • as prevention for persons over 40 years.
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Contraindications

Melatonin instruction, price on the Internet
  • pregnancy;
  • lactation;
  • children under 12 years old.

Dosage and administration

Melatonin is intended for ingestion. Adults are usually prescribed 1-2 tablets immediately before bedtime. The tablet should be washed down with water and swallowed whole without biting. Children after 12 years, one tablet at bedtime.

Overdose

Not seen. There are data on the admission of up to 24 grams within one month, although such doses are not recommended.

Side effects

In extremely rare cases, when taking Melatonin, adverse reactions were observed, such as discomfort in the stomach, “heavy head”, headache, depression. It is necessary to inform your doctor about all adverse (unusual) events, including those not listed in the package insert.

special instructions

Use during pregnancy and lactation

The drug is contraindicated for use during pregnancy and lactation.

Interaction with other drugs and other forms of interaction

Aspirin, beta blockers can lead to a decrease in melatonin levels in the body. Sedative antidepressants, tranquilizers and other sedatives can reduce the expected effect. Persons suffering from hormonal or autoimmune diseases, deep depressive disorders, epilepsy, leukemia should consult with your doctor.

Storage conditions

Store at room temperature out of the reach of children.

The drug should not be consumed after the expiration date indicated on the package.

Note!

This is a description of the drug. Melatonin There is a simplified author’s version of the site apteka911, created on the basis of instructions / s for use. Before purchasing or using the drug, you should consult with your doctor and familiarize yourself with the original manufacturer’s instructions (included with each package of the drug).

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Information about the drug is provided solely for informational purposes and should not be used as a guide to self-treatment. Only a doctor can decide on the appointment of the drug, as well as determine the dose and how to use it.